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CMC Documentation & Innovations

Regulatory CMC expertise for drug development from discovery to manufacturing

Overview

Our regulatory CMC team provides expertise in all areas of product development, from small molecules to biologics. We provide regulatory advice and compile your application for drug substances, pharmaceutical excipients, packaging materials, and drug-device combination products.

We offer regulatory advice and compile your application using phase-appropriate standards, from early development through manufacturing, to accelerate your project and advance your product to the clinic.

Scientific Report Writing

We specialize in creating scientific and technical reports using a dossier-centric approach. This ensures consistency, completeness, and readability while keeping the final application in mind.

Our reports are designed to meet regulatory requirements and provide comprehensive documentation for your drug development program.

Drug Product Reports

The following reports are essential in the pharmaceutical industry and play a significant role in ensuring product quality, safety, and efficacy:

Development Reports

  • Drug product formulation development reports
  • Drug product manufacturing process development reports
  • Technology transfer reports

Quality & Investigation

  • Investigation reports
  • Criticality analysis reports
  • Quality control reports

Drug Substances Documentation

The following documents are integral for ensuring the safety and efficacy of drug substances:

Safety Assessment

  • Mutagenicity assessment reports
  • Nitrosamine risk assessment reports
  • Criticality analysis reports

Process & Quality

  • Reports on origin and fate of impurities
  • Regulatory starting material justification reports
  • Process development reports

Proven Acceptable Ranges (PAR)

We provide comprehensive PAR justification reports that demonstrate the acceptable ranges for critical process parameters, ensuring robust manufacturing processes and regulatory compliance.

Analytical Development

Stability & Dissolution

  • Stability reports
  • Dissolution reports including USP Type IV
  • Microbiology reports

Assay & Characterization

  • Assay development, including impurity
  • Chromophore and non-chromophore detectors
  • Particle size development report (orthogonal techniques)

Physical Properties

  • Solid state report
  • Rheological report

Advanced Techniques

  • LC analysis using CAD and RI detectors
  • Free drug and trace level impurities detection

Regulatory Support Services

Specifications & Studies

  • Justification of specifications
  • Stability studies and selection and design
  • Briefing Books for scientific advice

Strategy & Compliance

  • Gap analysis
  • Filing and registration strategy
  • Variations and Renewals

Why Choose Our CMC Services?

Expert Team

Experienced regulatory professionals with deep understanding of global requirements.

Comprehensive Coverage

End-to-end CMC support from early development through commercialization.

Regulatory Excellence

Proven track record of successful regulatory submissions and approvals.

Ready to Accelerate Your Regulatory Journey?

Contact our CMC documentation team to discuss your regulatory needs and how we can support your drug development program.